A cure finally for leukaemia.WOOHOO!!!

[fuzzywuzzy]

Within a year!!!!!



Melbourne researchers make breakthough in treatment for aggressive leukaemia - ABC News (Australian Broadcasting Corporation)

The Peter MacCallum Cancer Centre has come up with a double-barrelled approach it is hoped will lead to long-term survival for those suffering from the blood cancer.

A mutant enzyme called JAK2 drives and feeds a virulent form of the disease that has proved resistant to therapy.

"Not only do they grow very quickly and the tumours spread more rapidly but they're often refractory to standard chemotherapies up front," Professor Ricky Johnstone, Assistant Director of Research at the Peter MacCallum Centre, said.

"These are things that are very difficult to treat because of how quickly they spread but, in addition, they cannot be treated by the common chemotherapy."

However, the dual-pronged attack has already proved successful in completely curing this form of leukaemia in mice.

Professor Johnstone said: "If we think about a tumour cell as a tree and if we think about this JAK2 protein being the tree, what we want to do is target that tree at two points: we want to cut off the leaves with one drug and then we want to deplete the root system and, importantly, the tap-root at another level.

"We think that the best way to kill that tree and therefore the tumour cell would be this dual approach - remove the leaves, remove the roots and then completely diminish the survival and nourishment pathway for that tree and, therefore, kill the tumour cell."

Researchers hope the treatment will be available to patients within a year.

[Bryn Mawr]

fuzzywuzzy;1441261 wrote: Within a year!!!!!



Melbourne researchers make breakthough in treatment for aggressive leukaemia - ABC News (Australian Broadcasting Corporation)


OK, it's only one form of Leukemia but an important breakthrough nonetheless. Here's hoping that it gets through human testing.

[fuzzywuzzy]

just saw an interview this morning on this drug. 67 people have been adminsitered the drug and results so far are 21% cleared of Leakaemia 61% in transitional or total remission . It was stated that those cleared are not 'cured' if they stop taking the drug it will come back.

I don't care what language you speak, that's great in anyones' book, mainly because it has, in this one 1st trial, eliminated bone marrow transplants for these individuals ...WOOHOO!!!! Next trial is an international trial. So if you know anyone with this common form of the illness get them to sign up immediately!!!!!!

[Wandrin]

That's good news!

[Bryn Mawr]

fuzzywuzzy;1442551 wrote: just saw an interview this morning on this drug. 67 people have been adminsitered the drug and results so far are 21% cleared of Leakaemia 61% in transitional or total remission . It was stated that those cleared are not 'cured' if they stop taking the drug it will come back.

I don't care what language you speak, that's great in anyones' book, mainly because it has, in this one 1st trial, eliminated bone marrow transplants for these individuals ...WOOHOO!!!! Next trial is an international trial. So if you know anyone with this common form of the illness get them to sign up immediately!!!!!!


82% positive result with, presumably, no extreme side effects is an outstanding outcome.