Katy1 wrote: Hi Ted,
With the vitamin D issue in mind....why is that some of the hottest States (receiving the most sunlight) in the USA are also the most obese and the Scandinavian countries who's daylight is restricted and weather affects, has some of the lowest obesity levels in the world?
It is an interesting theory re: vitamin D but doesn't seem entirely right!
KatyIt's obviously a complex question and I'm not for one moment suggesting that vitamin d3 is the answer to all ailments however it's role is far more important than was previously thought and it's a pity that because it's free from sunlight nobody has a financial interest in promoting it thus their is no money available for researching it's effects. So much for capitalism.
But if you look at a few basic questions you see it must have a role.
Weight increases with higher latitude, Weight increases with lower altitude Weight increases in the winter Ann Hum Biol. 1988 Sep-Oct;15(5):353-64.
While the seasonal variation in weight is well known, the variations with latitude and altitude are less well known. Different explanations exist for all three associations but vitamin D provides a parsimonious explanation as vitamin D decreases with higher latitude, lower altitude and with the winter.
When aboriginal populations migrate from high altitude to low altitude, without significantly changing their diet, body fat increases. As vitamin D production is less at lower altitude, a vitamin D theory of obesity would predict such a change. High Alt Med Biol. 2004 Spring;5(1):27-31.
Saudi Arabians, who often cover their skin and make little vitamin D, show no associations between altitude and weight, while central Asians, who do not cover their skin, are leaner at higher altitudes where more vitamin D would be made in the skin.
Ann Hum Biol. 1995 Sep-Oct;22(5):459-65.
Ann Hum Biol. 2000 Jan-Feb;27(1):19-28.
Current scientific literature makes it likely that vitamin D reduces weight.
Higher calcium intake is consistently associated with lower body weight, a topic recently reviewed by Heaney. As vitamin D significantly increases calcium absorption, it seems likely that higher intakes of vitamin D would decrease body weight, even if the vitamin itself had no direct effect on weight.
J Am Coll Nutr. 2002 Apr;21(2):152S-155S.
Genetic abnormalities of the vitamin D receptor (called VDR polymorphisms) are associated with body weight and fat mass.
Patients with VDR polymorphisms have reduced vitamin D activity at their receptors and usually show an increased incidence of vitamin D related diseases. Although VDR polymorphism studies are often contradictory, they tend to show associations with body weight.
Eur J Endocrinol. 2004 Mar;150(3):323-8.
Calcif Tissue Int. 1995 Aug;57(2):161-2.
Eur J Endocrinol. 2001 Apr;144(4):385-9.
Blood parathyroid levels, which are elevated in vitamin D deficiency, predict obesity.
Vitamin D deficiency is associated with elevated parathyroid hormone levels. If vitamin D deficiency caused obesity, than obese patients should have elevated blood parathyroid hormone levels. In fact, the association between obesity and elevated parathormone levels is well known.
Eur J Endocrinol. 2004 Aug;151(2):167-72.
Scientists have found that vitamin D blood levels are lower in obese subjects than in thin subjects.Morbidly obese patients have been reported to present with vitamin D insufficiency 80% of the patients presented low vitamin D levels
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_docsum
If vitamin D deficiency explains some cases of obesity, then studies have consistently shown that 25(OH)D levels are lower in obese subjects.
Starting in 1981, at least ten studies have shown exactly that, some of which are listed below. Some studies have also shown a linear association, that is, the higher your 25(OH)D levels, the less you weigh. Not only weight, but percentage of body fat, increases as 25(OH)D levels fall.
Am J Clin Nutr. 1981 Nov;34(11):2359-63.
J Clin Invest. 1985 Jul;76(1):370-3.
Obes Surg. 1993 Nov;3(4):421-424.
J Clin Endocrinol Metab. 2003 Jan;88(1):157-61.
Obese subjects obtain lower 25(OH)D levels when exposed to ultraviolet light or when they take supplemental vitamin D. Obese subjects appear to deposit some their vitamin D in their excessive fatty tissue, thus impairing their ability to raise their 25(OH)D levels.
Am J Clin Nutr. 2000 Sep;72(3):690-3.
The theory that vitamin D deficiency contributes to some cases of obesity, would mean that obesity is linked with other diseases associated with vitamin D deficiency, such as cancer, diabetes and heart disease.
Obesity and vitamin D deficiency are comorbid with numerous diseases such as heart disease, hypertension, diabetes, osteoarthritis, osteoporosis, depression and even periodontal disease. This is consistent with the theory that vitamin D deficiency plays a role in obesity.
J Clin Endocrinol Metab. 2004 Jun;89(6):2583-9.
Can J Public Health. 2004 May-Jun;95(3):179-83.
J Periodontol. 2003 May;74(5):610-5.
As obesity is associated with early death, and low vitamin D levels are more likely in the winter, then you are more likely to die in the winter. Scientists have known about and debated the cause of excess winter deaths for years.
If vitamin D deficiency is one of the treatable causes of obesity, then a study has shown that the more vitamin D in your diet, the less you weigh.
A Norwegian group reported just that. The authors concluded, “placebocontrolled
intervention studies with calcium and vitamin D, in which the primary end point is
weight change, are warranted.â€
J Nutr. 2003 Jan;133(1):102-6.
Above research somewhat edited and updated a bit comes from John Cannell, MD
The Vitamin D Council
http://www.cholecalciferol-council.com/
Boosted Vitamin D Intake for Cancer Prevention?
http://www.medpagetoday.com/Pediatrics/ ... n/tb1/2404
Shows that taking a serum level of 20 ng/mL or lower (a person spending every day outdoors with arms legs exposed would have naturally about 75ng/ml) as a sign of deficiency half of the elderly in the U.S. are vitamin D deficient as well as 35% to 40% of the younger population. Dark skinned people of course need six to ten times more exposure that white skinned hence if they stay indoors by the air conditioning, work shifts, drive in cars and never spend time sunbatheing outdoors their levels will be lower than ideal.
I don't know anything about Scandinavia and sun practices. Will try to find out but I seem to have the opinion that they crave the sunlight , take lots of holdays in sunny places and spend rather more time naked and exposing their skin to sunlight than is customary elsewhere.